In order to understand the current global pandemic of diet related disease, we must see the problem of sugar in the diet to be a matter of metabolic disorder – the progenitor of many conditions affecting multiple organs and systems of the human body, and manifesting in obesity, CVD, and many other disease states.
For example, there are more metabolically sick thin people than overweight people, and fatty liver disease (typically hidden) is not always obvious or discussed in the popular media, despite being one of the fastest growing chronic diseases on earth.
In other words, it is fundamental to focus on how sugar is metabolized and the wide range of negative physiological impacts that result from the metabolic dysregulation that sugar causes in the quantities currently being consumed by the average human being. Another key question is “what is sugar?”, and how different forms of sugar are metabolized (added sugars, processed carbohydrates, etc.), and how they metabolize differently at different doses and in combination with other sugars.

Dr. Robert Lustig explaining the relationship between metabolism of sugar and fatty liver disease.

Diagram of the Inclusive Model of Metabolic Disease (Dr. Robert Lustig)